A new pentacyclic ergosteroid from fungus Aspergillus sp. ScSiO41211 derived of mangrove sediment sample

Abstract

Chemical investigation of the fungus Aspergillus sp. SCSIO41211 derived of mangrove sediment sample afforded a ergostane-type pentacyclic steroid, (22S, 23R)-12α,14α,23α-trihydroxy-16,22-epoxy-ergosta-4,8-dien-3,11-dione (1), together with seven known compounds, flavacol (2), aspergilliamide (3), ochratoxin A methyl ester (4), ochratoxin A ethyl ester (5), dihydroaspyrone (6), aspilactonol E (7) and aspilactonol F (8). The structures were determined on the basis of NMR and MS analysis. The isolated compounds were tested for their antiviral activity against H3N2 and EV71 viruses, cytotoxic, and antituberculosis effects. Among them, compounds 2 and 5 showed significant cytotoxicity against ten human cancer cell lines. None of the compounds displayed a significant antiviral activity against H3N2 and EV71 viruses nor antimycobacterial activities.