Central and Peripheral Retina Arise through Distinct Developmental Paths

6Citations
Citations of this article
35Readers
Mendeley users who have this article in their library.

Abstract

In the mature eye, three distinct tissue fates, retina, ciliary body, and iris, arrange with a strict linear organization along the central (back) to peripheral (front) axis. The establishment of this topographical relationship within the optic vesicle is not well understood. We use a targeted vital labeling strategy to test the derivation of mature eye tissues from the optic vesicle of the chick embryo. Fate mapping uncovers two distinct origins of the neural retina. Contrary to expectations, the central neural retina has a discrete origin within the posterior optic vesicle. The peripheral retina derives from the distal optic vesicle, sharing a common origin with more peripheral tissue fates. This study identifies for the first time two distinct retinal sub-domains, central and peripheral, which arise during embryogenesis. Identification of these discrete retinal compartments provides a framework for understanding functional and disease processes throughout retinal tissue. © 2013 Venters et al.

Cite

CITATION STYLE

APA

Venters, S. J., Mikawa, T., & Hyer, J. (2013). Central and Peripheral Retina Arise through Distinct Developmental Paths. PLoS ONE, 8(4). https://doi.org/10.1371/journal.pone.0061422

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free