Catalyst-free alkylation of aminopyrazole by isatin in water

Abstract

Reactions of isatins with 5-aminopyrazole afforded the 3-(5-aminopyrazol-4-yl)-3-hydroxy-2-oxindolines in good to excellent yields in refluxing water. No catalysts were required in the process. The new method exhibited the characteristics including green process, high yields, easy operation, and mild reaction conditions. © 2013 The Author(s).