Skip to content

Natural resources for optogenetic tools

5Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Photoreceptors are found in all kingdoms of life and mediate crucial responses to environmental challenges. Nature has evolved various types of photoresponsive protein structures with different chromophores and signaling concepts for their given purpose. The abundance of these signaling proteins as found nowadays by (meta-)genomic screens enriched the palette of optogenetic tools signifi cantly. In addition, molecular insights into signal transduction mechanisms and design principles from biophysical studies and from structural and mechanistic comparison of homologous proteins opened seemingly unlimited possibilities for customizing the naturally occurring proteins for a given optogenetic task. Here, a brief overview on the photoreceptor concepts already established as optogenetic tools in natural or engineered form, their photochemistry and their signaling/design principles is given. Finally, so far not regarded photosensitive modules and protein architectures with potential for optogenetic application are described.

Cite

CITATION STYLE

APA

Mathes, T. (2016). Natural resources for optogenetic tools. In Methods in Molecular Biology (Vol. 1408, pp. 19–36). Humana Press Inc. https://doi.org/10.1007/978-1-4939-3512-3_2

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free