In a recent issue of Molecular Cell, Shiotani and Zou (2009) elucidate the biochemical mechanism underlying sequential ATM and ATR activation at DNA double-strand breaks, demonstrating that resection transforms ATM substrates into ATR substrates. © 2009 Elsevier Inc. All rights reserved.
Rhind, N. (2009, March 27). Changing of the Guard: How ATM Hands Off DNA Double-Strand Break Signaling to ATR. Molecular Cell. https://doi.org/10.1016/j.molcel.2009.03.004