Characterization of human thioredoxin-like-1: Potential involvement in the cellular response against glucose deprivation

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Abstract

The thioredoxin system, composed of thioredoxin (Trx) and thioredoxin reductase (TrxR), emerges as one of the most important thiol-based systems involved in the maintenance of the cellular redox balance. Thioredoxin-like-1 (TXL-1) is a highly conserved protein comprising an N-terminal Trx domain and a C-terminal domain of unknown function. Here we show that TXL-1 is a substrate for the cytosolic selenoprotein TrxR-1. In situ hybridization experiments demonstrates high expression of Txl-1 mRNA in various areas of central nervous system and also in some reproductive organs. Glucose deprivation, but not hydrogen peroxide treatment, reduced the levels of endogenous TXL-1 protein in HEK-293 cell line. Conversely, overexpression of TXL-1 protects against glucose deprivation-induced cytotoxicity. Taken together, the finding that Txl-1 mRNA is highly expressed in tissues which use glucose as a primary energy source and the modulation of TXL-1 levels upon glucose deprivation indicate that TXL-1 might be involved in the cellular response to sugar starvation stress. © 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Jiménez, A., Pelto-Huikko, M., Gustafsson, J. Å., & Miranda-Vizuete, A. (2006). Characterization of human thioredoxin-like-1: Potential involvement in the cellular response against glucose deprivation. FEBS Letters, 580(3), 960–967. https://doi.org/10.1016/j.febslet.2006.01.025

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