Citations of this article
Mendeley users who have this article in their library.
Get full text


Arrays of monolithically integrated Mach-Zehnder interferometers were fabricated by standard silicon technology and applied to the label-free real-time monitoring of biomolecular interactions. Chips accommodating 10 MZIs were functionalized with recognition biomolecules and encapsulated in wafer scale. Detection is based on Frequency-Resolved Mach-Zehnder Interferometry, a new concept that takes advantage of the broad-band input spectrum by monitoring the changes for every input frequency. The sensitivity of the device in terms of refractive index changes (Δn) was calculated using isopropanol/water solutions. A detection limit of Δn = 4 × 10(-6) was calculated. The bioanalytical capabilities of the device there demonstrated through model binding assays (biotin/streptavidin) as well as the detection of total prostate specific antigen in serum samples using devices coated with antigen-specific monoclonal antibody. Detection limits at the pM range were determined.




Ahmad, S. N., Rather, M. A., Jabeen, F., Bhat, K. A., & Khuroo, M. A. (2017). Chemical Composition of the Essential oil of Sambucus wightiana Wall. ex. Wight & Arn from Kashmir Himalayas. Adv. Biomed. Pharma, 4(2), 61–64. https://doi.org/10.1109/IEMBS.2011.6091886

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free