Chemical genetics: Adding to the developmental biology toolbox

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Recent advances in cell and molecular biology have generated important tools to probe developmental questions. In addition, new genetic model systems such as Danio rerio now make large-scale vertebrate early developmental mutant screens feasible. Nonetheless, some developmental questions remain difficult to study because of the need for finer temporal, spatial, or tuneable control of gene function within a developmental system. New uses for old teratogens as well as novel chemical modulators of development have begun to fill this void.




Yeh, J. R. J., & Crews, C. M. (2003, July 1). Chemical genetics: Adding to the developmental biology toolbox. Developmental Cell.

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