Cholesterol monohydrate nucleation in ultrathin films on water

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Abstract

The growth of a cholesterol crystalline phase, three molecular layers thick at the air-water interface, was monitored by grazing incidence x-ray diffraction and x-ray reflectivity. Upon compression, a cholesterol film transforms from a monolayer of trigonal symmetry and low crystallinity to a trilayer, composed of a highly crystalline bilayer in a rectangular lattice and a disordered top cholesterol layer. This system undergoes a phase transition into a crystalline trilayer incorporating ordered water between the hydroxyl groups of the top and middle sterol layers in an arrangement akin to the triclinic 3-D crystal structure of cholesterol · H2O. By comparison, the cholesterol derivative stigmasterol transforms, upon compression, directly into a crystalline trilayer in the rectangular lattice. These results may contribute to an understanding of the onset of cholesterol crystallization in pathological lipid deposits.

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Rapaport, H., Kuzmenko, I., Lafont, S., Kjaer, K., Howes, P. B., Als-Nielsen, J., … Leiserowitz, L. (2001). Cholesterol monohydrate nucleation in ultrathin films on water. Biophysical Journal, 81(5), 2729–2736. https://doi.org/10.1016/S0006-3495(01)75915-2

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