Cmv-1, a genetic locus that controls murine cytomegalovirus replication in the spleen

236Citations
Citations of this article
31Readers
Mendeley users who have this article in their library.

Abstract

The genetic basis of the control of acute splenic MCMV infection was studied after intraperitoneal inoculation of the virus. Classical Mendelian analyses using C57BL/6 (resistant) and BALB/c (susceptible) parental strains disclosed an autosomal dominant non-H-2 gene that regulates splenic virus replication. The probable location of this gene, to which we have assigned the symbol Cmv-1, is on chromosome 6 as defined by the strain distribution pattern of splenic MCMV replication in CXB recombinant inbred mice. Although there is a similar hierarchy of resistance to MCMV and HSV-1 with respect to the C57BL and BALB genetic backgrounds, the strain distribution pattern of HSV-1 replication in recombinant inbred mice suggests that Cmv-1 is not involved in restricting the spread of this virus. This is the first clear identification of a non-H-2 gene regulating the magnitude of MCMV infection. Elucidation of the function of this gene may be a fundamental step towards understanding the control of systemic CMV infection.

Cite

CITATION STYLE

APA

Scalzo, A. A., Fitzgerald, N. A., Simmons, A., La Vista, A. B., & Shellam, G. R. (1990). Cmv-1, a genetic locus that controls murine cytomegalovirus replication in the spleen. Journal of Experimental Medicine, 171(5), 1469–1483. https://doi.org/10.1084/jem.171.5.1469

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free