C-Myc regulates transcriptional pause release

726Citations
Citations of this article
912Readers
Mendeley users who have this article in their library.

Abstract

Recruitment of the RNA polymerase II (Pol II) transcription initiation apparatus to promoters by specific DNA-binding transcription factors is well recognized as a key regulatory step in gene expression. We report here that promoter-proximal pausing is a general feature of transcription by Pol II in mammalian cells and thus an additional step where regulation of gene expression occurs. This suggests that some transcription factors recruit the transcription apparatus to promoters, whereas others effect promoter-proximal pause release. Indeed, we find that the transcription factor c-Myc, a key regulator of cellular proliferation, plays a major role in Pol II pause release rather than Pol II recruitment at its target genes. We discuss the implications of these results for the role of c-Myc amplification in human cancer. PaperClip: © 2010 Elsevier Inc.

Author supplied keywords

Cite

CITATION STYLE

APA

Rahl, P. B., Lin, C. Y., Seila, A. C., Flynn, R. A., McCuine, S., Burge, C. B., … Young, R. A. (2010). C-Myc regulates transcriptional pause release. Cell, 141(3), 432–445. https://doi.org/10.1016/j.cell.2010.03.030

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free