Cognitive Decline in Older Persons Initiating Anticholinergic Medications

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Abstract

Background:This study examines the effect of initiating medications with anticholinergic activity on the cognitive functions of older persons.Methods:Participants were 896 older community-dwelling, Catholic clergy without baseline dementia. Medication data was collected annually. The Anticholinergic Cognitive Burden Scale was utilized to identify use of a medication with probable or definite anticholinergic activity. Participants had at least two annual cognitive evaluations.Results:Over a mean follow-up of 10 years, the annual rate of global cognitive function decline for never users, prevalent users, and incident users was -0.062 (SE = 0.005), -0.081(SE = 0.011), and -0.096 (SE = 0.007) z-score units/year, respectively. Compared to never users, incident users had a more rapid decline (difference = -0.034 z-score units/year, SE = 0.008, p<0.001) while prevalent users did not have a significantly more rapid decline (p = 0.1).Conclusions:Older persons initiating a medication with anticholinergic activity have a steeper annual decline in cognitive functioning than those who are not taking these medications.

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APA

Shah, R. C., Janos, A. L., Kline, J. E., Yu, L., Leurgans, S. E., Wilson, R. S., … Tsao, J. W. (2013). Cognitive Decline in Older Persons Initiating Anticholinergic Medications. PLoS ONE, 8(5). https://doi.org/10.1371/journal.pone.0064111

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