Cognitive deficits are extremely disabling manifestations of schizophrenia that often predate the onset of illness and persist throughout its course. They are also present in the healthy relatives of individuals with schizophrenia, suggesting that they are markers of genetic vulnerability to illness, or 'endophenotypes.' This article describes the cognitive deficits that seem most central to schizophrenia and that hold the most promise for shedding light on its pathophysiology. Challenges to the quest to identify specific cognitive deficits in schizophrenia are addressed, and integrative explanations of cognitive dysfunction are proposed. Finally, recent advances in genetics and neuroimaging that may illuminate the mechanisms of both cognitive deficits and schizophrenia are discussed. © 2009 Elsevier Ltd All rights reserved.
Manoach, D. S. (2010). Cognitive Deficits in Schizophrenia. In Encyclopedia of Neuroscience (pp. 1101–1109). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.00425-3