Combinatorial approaches to affinity chromatography

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A new armoury of protein purification tools is required to support rapid advances in high-throughput genomics and proteomics, which are predicted to lead to the discovery, isolation, characterisation and manufacture of a number of new biopharmaceutical proteins. Computer-aided molecular design, combinatorial (bio)chemistry and high-throughput screening techniques are now being exploited to identify highly selective ligands for use in the purification of these proteins by affinity chromatography.




Lowe, C. R. (2001, June 1). Combinatorial approaches to affinity chromatography. Current Opinion in Chemical Biology. Elsevier Ltd.

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