Common threads in cardiac fibrosis, infarct scar formation, and wound healing

50Citations
Citations of this article
115Readers
Mendeley users who have this article in their library.

Abstract

Wound healing, cardiac fibrosis, and infarct scar development, while possessing distinct features, share a number of key functional similarities, including extracellular matrix synthesis and remodeling by fibroblasts and myofibroblasts. Understanding the underlying mechanisms that are common to these processes may suggest novel therapeutic approaches for pathologic situations such as fibrosis, or defective wound healing such as hypertrophic scarring or keloid formation. This manuscript will briefly review the major steps of wound healing, and will contrast this process with how cardiac infarct scar formation or interstitial fibrosis occurs. The feasibility of targeting common pro-fibrotic growth factor signaling pathways will be discussed. Finally, the potential exploitation of novel regulators of wound healing and fibrosis (ski and scleraxis), will be examined.

Cite

CITATION STYLE

APA

Czubryt, M. P. (2012, November 1). Common threads in cardiac fibrosis, infarct scar formation, and wound healing. Fibrogenesis and Tissue Repair. https://doi.org/10.1186/1755-1536-5-19

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free