The aim of this study was to investigate the application value of<br />thyroid puncture biopsy guided by contrast-enhanced ultrasound (CEUS). A<br />total of 48 patients with 51 solid thyroid nodules (suspected papillary<br />thyroid carcinoma, PTC) were enrolled in the study. Following detection<br />by conventional ultrasonography and CEUS, puncture biopsy of the<br />suspicious lesions guided by conventional ultrasonography and CEUS was<br />conducted, respectively. Then, pathological diagnosis was performed. The<br />number of PTC positive nodules and puncture points detected by the two<br />methods were compared. In 51 nodules with 310 punctures, 44 nodules<br />(86.3%, 44/51) and 240 punctures (77.4%, 240/310) were pathologically<br />diagnosed as PTC. In the 44 nodules diagnosed as PTC, 43 and 34 nodules<br />were detected by CEUS and conventional ultrasound, respectively, with a<br />significant difference between the two methods (P=0.022). Eleven (25%)<br />nodules were independently detected by CEUS. The sensitivity and<br />accuracy of puncture point detection by CEUS (82.9 and 82.6%,<br />respectively) were significantly higher compared with those of<br />conventional ultrasound (48.3 and 56.5%, respectively; P<0.001). The<br />specificity of puncture points detected by CEUS (81.4%) was<br />significantly lower compared with that by conventional ultrasound<br />(84.3%; P=0.009). Compared with conventional ultrasound, a greater<br />number of PTC-positive nodules were detected by CEUS, with increased<br />sensitivity and accuracy of the puncture points.
Li, F., & Luo, H. (2013). Comparative study of thyroid puncture biopsy guided by contrast-enhanced ultrasonography and conventional ultrasound. Experimental and Therapeutic Medicine, 5(5), 1381–1384. https://doi.org/10.3892/etm.2013.1016