© Medicina Oral S. L. Objectives: The purpose of this study was to compare the use of amoxicillin (1g) vs amoxicillin and clavulanate (875/125mg) after extraction of retained third molars for prevention of infectious complications. Study Design: The study involved 546 patients attending for removal a retained third molar and divided in to two groups: Group 1 - amoxicillin and clavunate (875/125mg) group (n=257) and Group 2 - amoxicillin (1g) group (n=289). All patients were recalled for investigating the possibility of infection, presence of diarrhea and further analgesic intake. Results: From a total of 546 patients, the frequency of infection was 1.4%, without no statistically differences between the two groups. Group 1 showed statistically higher presence of patients with gastrointestinal complications (p > 0.05). In 546 patients, 2.7% of patients reported severe pain that would not relieve with medication. Conclusions: The results of our study show that the use of amoxicillin (1g) and amoxicillin and clavunate (875/125mg) is similar efficacious in preventing infection after retained third molar extraction but amoxicillin and clavunate (875/125mg) produces more gastrointestinal discomfort.
Iglesias-Martín, F., García-Perla-García, A., Yañez-Vico, R., Aced-Jiménez, E., Arjona-Gerveno, E., González-Padilla, J. D., … Torres-Lagares, D. (2014). Comparative trial between the use of amoxicillin and amoxicillin clavulanate in the removal of third molars. Medicina Oral Patologia Oral y Cirugia Bucal, 19(6), e612–e615. https://doi.org/10.4317/medoral.19778