Comparison of bovine jugular vein with pulmonary homograft conduits in children less than 2 years of age

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Abstract

Objectives: The optimal pulmonary valved conduit for infants and small children remains controversial. This report compares the initial insertion outcome of small caliber bovine jugular vein (BJV) (12-14mm) with pulmonary homografts (PHs) (10-15mm) in patients under age 2. Methods: From December 1998 to August 2009, 84 children (mean age 8.4 ± 8.5 months) received BJV (n=51) or PH (n=32) conduits. Mean Z score for BJV was 2.2 (range: -0.8 to 3.3) and for PH 2.1 (range: 0.8-4.2; P=0.2). The two cohorts were similar with respect to age, BSA, conduit indication, bypass and cross-clamp time. Graft dysfunction is defined as right ventricular outflow tract obstruction with peak echo-Doppler gradient >40mmHg and/or grade III/IV conduit valve regurgitation. Graft failure is defined as need for conduit replacement or need for catheter or surgical re-intervention. Follow-up was greater in number in homografts (BJV, 4.4 ± 3.0 years vs PH, 5.9 ± 3.6 years; P=0.05). Results: Early and late mortality were similar (BJV, 80%; PH 88%; P=0.55). No death was graft related. Freedom from dysfunction was improved at 5 and 10 years with BJV (BJV, 90% at 85% vs PH, 71% and 24% P<0.05). Conduit failure trended higher in the PH cohort at 5 and 10 years (BJV, 85% and 67% vs PH, 75% and 45%; P=0.06). Freedom from explantation was significantly better for BJV patients (BJV, 85% vs PH, 47% P<0.001. Freedom from distal conduit stenosis was similar (BJV, 52% vs PH, 44% P=0.36). Conclusions: This study suggests that the early performance of small BJV may be more advantageous than homografts. A BJV conduit is an appropriate first choice for conduit replacement in patients less than 2 years of age. © 2010 European Association for Cardio-Thoracic Surgery.

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APA

Fiore, A. C., Ruzmetov, M., Huynh, D., Hanley, S., Rodefeld, M. D., Turrentine, M. W., & Brown, J. W. (2010). Comparison of bovine jugular vein with pulmonary homograft conduits in children less than 2 years of age. European Journal of Cardio-Thoracic Surgery, 38(3), 318–325. https://doi.org/10.1016/j.ejcts.2010.01.063

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