Background The promising postsurgical weight loss and remission of type 2 diabetes (T2D) from bariatric surgery can be attributed to modified eating physiology after surgical procedures. We sought to investigate the changes in the parameters of consumption behaviors and appetite sensations induced by a mixed meal tolerance test, and to correlate these alterations with age, body mass index, C-peptide levels, and duration of T2D 1 year after bariatric surgery. Methods. A total of 16 obese patients with T2D who underwent mini-gastric bypass (GB) and 16 patients who underwent sleeve gastrectomy (SG) were enrolled in this study and evaluated using a mixed meal tolerance test one year after surgery. A visual analogue scale was used for scoring appetite sensation at different time points. The area under the curve (AUG) and the incremental or decremental AUG (Delta AUC) were compared between the two groups. Results. One year after surgery, a decreasing trend in the consumption time was observed in the GB group compared to the SG group, while the duration of T2D before surgery was negatively correlated with the post-operative consumed time in those after GB. Patients who underwent GB had significantly higher fasting scores for fullness and desire to eat, higher AUC(0'-180') of scores for desire to eat, as well as more effective post-meal suppression of hunger and desire to eat compared with those undergoing with Delta AUC(0'-180'), for hunger and Delta AUC(0'-180) one year after surgery. Post-operative C-8peptide esleirveeltsoweaetreinntehgeatGivBelgyrcoourpr, whileelated negatively correlated with Delta AUC(0'-180') lfor fullness in the SG group. Discussion. Patients with T2D after either GB or SG exhibit distinct nutrient-induced consumption behaviors and appetite sensations post-operatively, which may account for the differential effects on weight loss and glycemic control after different surgery.
Yeh, C., Huang, H.-H., Chen, S.-C., Chen, T.-F., Ser, K.-H., & Chen, C.-Y. (2017). Comparison of consumption behavior and appetite sensations among patients with type 2 diabetes mellitus after bariatric surgery. PeerJ, 5, e3090. https://doi.org/10.7717/peerj.3090