Comparison of hypertonic saline versus normal saline on cytokine profile during CABG

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Background and the purpose of the study. Blood contact with artificial surfaces of the extracorporeal circuit and ischemia-reperfusion injury in CABG with CPB, may lead to a systemic inflammatory response. Hypertonic saline have been recently investigated as a fluid in order to decrease inflammatory response and cytokines generation in patients undergo cardiac operations. Our purpose is to study the prophylactic effect of HS 5% infusion versus NS on serum IL-6 as an inflammatory & IL-10 as an anti-inflammatory biomarker in CABG patients. Methods. The present study is a randomized double-blinded clinical trial. 40 patients undergoing CABG were randomized to receive HS 5% or NS before operation. Blood samples were obtained after receiving HS or NS, just before operation, 24 and 48 hours post-operatively. Plasma levels of IL-6 and IL-10 were measured by ELISA. Results and major conclusion. Patients received HS had lower levels of IL-6 and higher level of IL-10 compared with NS group, however these differences were not statistically significant. Results of this study suggest that pre-treatment with small volume hypertonic saline 5% may have beneficial effects on inflammatory response following CABG operation. © 2012 Mazandarani et al.; licensee BioMed Central Ltd.




Mazandarani, M., Yousefshahi, F., Abdollahi, M., Hamishehkar, H., Barkhordari, K., Boroomand, M. A., … Mojtahedzadeh, M. (2012). Comparison of hypertonic saline versus normal saline on cytokine profile during CABG. DARU, Journal of Pharmaceutical Sciences, 20(1).

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