The limitations of conventional machining and assembly techniques require that designs for quadrupole mass analyzers with rod diameters less than a millimeter are not merely scale versions of larger instruments. We show how silicon planar processing techniques and microelectromechanical systems (MEMS) design concepts can be used to incorporate complex features into the construction of a miniature quadrupole mass filter chip that could not easily be achieved using other microengineering approaches. Three designs for the entrance and exit to the filter consistent with the chosen materials and techniques have been evaluated. The differences between these seemingly similar structures have a significant effect on the performance. Although one of the designs results in severe attenuation of transmission with increasing mass, the other two can be scanned to m/z = 400 without any corruption of the mass spectrum. At m/z = 219, the variation in the transmission of the three designs was found to be approximately four orders of magnitude. A maximum resolution of M/ΔM = 87 at 10% peak height has been achieved at m/z = 219 with a filter operated at 6 MHz and constructed using rods measuring (508 ± 5) μm in diameter. © 2009 American Society for Mass Spectrometry.
Wright, S., Syms, R. R. A., O’Prey, S., Hong, G., & Holmes, A. S. (2009). Comparison of Ion Coupling Strategies for a Microengineered Quadrupole Mass Filter. Journal of the American Society for Mass Spectrometry, 20(1), 146–156. https://doi.org/10.1016/j.jasms.2008.08.019