Comparison of Oral Tolerance to ApoB and HSP60 Peptides in Preventing Atherosclerosis Lesion Formation in Apob48 − /Ldlr − Mice

  • Mundkur L
  • Mukhopadhyay R
  • Deshpande V
  • et al.
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Abstract

Antigen-specific immune modulation is emerging as an attractive therapeutic option to prevent atherosclerosis. We compared the efficacy of oral administration of peptides derived from apolipoprotein B (ApoB; 661–680) and heat shock protein 60 (HSP60; 153–163), in the prevention of atherosclerotic lesion formation hyperlipidemic low density lipoprotein receptordeficient (LDLr −/− ), apolipoprotein B-100 only (apoB 100/100 ) mice model. Oral administration of peptides induced tolerance as seen by an increase in regulatory T cells in the peripheral immune system. Tolerance to ApoB peptide reduced plaque development by 28.7% ( P<0.001 ) while HSP60 was effective in reducing lesion development by 26.8% in ApoB48/LDLr −/− mice. While tolerance to HSP60 resulted in increase in anti-inflammatory cytokines (IL10 and TGF- β ), ApoB tolerance was effective in reducing the lipid deposition in the lesion. Our results suggest that the two peptides have distinct mechanisms of controlling the development of atherosclerosis in mice.

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APA

Mundkur, L., Mukhopadhyay, R., Deshpande, V., Samson, S., Tarate, S., Varma, M., … Kakkar, V. V. (2013). Comparison of Oral Tolerance to ApoB and HSP60 Peptides in Preventing Atherosclerosis Lesion Formation in  Apob48 − /Ldlr −  Mice . Journal of Vaccines, 2013, 1–13. https://doi.org/10.1155/2013/212367

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