A comparison of the relative growth velocities with budesonide and fluticasone propionate in children with asthma

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Abstract

There have been no previous large, well-designed direct comparisons of the effects of fluticasone propionate (FP) and budesonide (BUD) on growth in children. This randomised, double-blind study compared the effects on growth of FP and BUD in children aged 6-9 years with persistent asthma. Following a 6-month run-in period (without inhaled corticosteroids), patients with normal growth velocity were randomised to 12 months' treatment with FP 100 μg bd (n = 114) or BUD 200 μg bd (n = 119). Growth velocity was determined by stadiometric height measurement. Lung function, asthma symptoms and use of relief medication were also assessed. Annualised mean growth velocity during run-in was comparable in the two groups (FP: 5.9 cm/yr; BUD: 6.0 cm/yr). During the treatment period, adjusted mean growth velocity was significantly higher in the FP than the BUD group (5.5 cm/yr vs 4.6 cm/yr; P < 0.001). Asthma control improved similarly in both treatment groups. Bone mineral density and overnight urinary cortisol:creatinine ratios were similar in the two groups. Drug-related adverse events were reported among 3% of FP-treated children, compared with 2% for BUD. In conclusion, this study demonstrates that FP for childhood asthma has significantly less impact on childhood growth velocity than a therapeutically equivalent dose of BUD. © 2006 Elsevier Ltd. All rights reserved.

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Ferguson, A. C., Van Bever, H. P., Teper, A. M., Lasytsya, O., Goldfrad, C. H., & Whitehead, P. J. (2007). A comparison of the relative growth velocities with budesonide and fluticasone propionate in children with asthma. Respiratory Medicine, 101(1), 118–129. https://doi.org/10.1016/j.rmed.2006.04.009

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