Complement-Mediated Glomerular Diseases: A Tale of 3 Pathways

32Citations
Citations of this article
59Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

A renewed interest in the role of complement in the pathogenesis of glomerular diseases has improved our understanding of their basic, underlying physiology. All 3 complement pathways—classical, lectin, and alternative—have been implicated in glomerular lesions both rare (e.g., dense deposit disease) and common (e.g., IgA nephropathy). Here we review the basic function of these pathways and highlight, with a disease-specific focus, how activation can lead to glomerular injury. We end by exploring the promise of complement-targeted therapies as disease-specific interventions for glomerular diseases.

Cite

CITATION STYLE

APA

Bomback, A. S., Markowitz, G. S., & Appel, G. B. (2016). Complement-Mediated Glomerular Diseases: A Tale of 3 Pathways. Kidney International Reports. Elsevier Inc. https://doi.org/10.1016/j.ekir.2016.06.005

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free