Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 which was sequenced using two independent sequencing meth-ods (454 pyrosequencing and Illumina). In rabbits, strain DAL-1 replicated better than the T. pallidum strain Nichols. The comparison of the complete DAL-1 genome sequence with the Nichols sequence revealed a list of genetic differences that are potentially responsible for the increased rabbit virulence of the DAL-1 strain.
Zobaníková, M., Mikolka, P., Čejková, D., Pospíšilová, P., Chen, L., Strouhal, M., … Šmajs, D. (2012). Complete genome sequence of Treponema pallidum strain DAL-1. Standards in Genomic Sciences, 7(1), 12–21. https://doi.org/10.4056/sigs.2615838