Complete genome sequence of Treponema pallidum strain DAL-1

22Citations
Citations of this article
16Readers
Mendeley users who have this article in their library.

Abstract

Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 which was sequenced using two independent sequencing meth-ods (454 pyrosequencing and Illumina). In rabbits, strain DAL-1 replicated better than the T. pallidum strain Nichols. The comparison of the complete DAL-1 genome sequence with the Nichols sequence revealed a list of genetic differences that are potentially responsible for the increased rabbit virulence of the DAL-1 strain.

Cite

CITATION STYLE

APA

Zobaníková, M., Mikolka, P., Čejková, D., Pospíšilová, P., Chen, L., Strouhal, M., … Šmajs, D. (2012). Complete genome sequence of Treponema pallidum strain DAL-1. Standards in Genomic Sciences, 7(1), 12–21. https://doi.org/10.4056/sigs.2615838

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free