Complete response to rivaroxaban in a case of invaginated thrombus thought to have extended through a patent foramen ovale with an accompanying pulmonary embolism

Abstract

Occurrence of paradoxical embolisms caused by deep venous thrombosis (DVT) is often encountered in the clinical setting. However, a thrombus that is invaginated from the right atrium into the left atrium (an impending paradoxical embolism) is rare. We report a case of an 80-year-old woman who had the complication of an impending paradoxical embolism and a pulmonary embolism. Because an indication of new anticoagulants was expanded to treatment of venous thromboembolism and oral administration became available, we initially administered edoxaban, which did not cause the thrombus to disappear. Therefore, we switched to rivaroxaban, which resulted in successful elimination of the thrombus. Our findings indicate the differences in effects between each novel oral anticoagulant.