Complex spatial dynamics of oncolytic viruses in vitro: Mathematical and experimental approaches

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Abstract

Traditional chemotherapy of cancers is characterized by strong side effects, while showing a low success rate in the long term control of tumors. Besides small molecule inhibitors, which have shown great promise, oncolytic viruses present an emerging specific treatment approach. They are engineered viruses that spread from tumor cell to tumor cell, killing them in the process. Non-tumor cells are generally not infected. While clinical trials have given rise to promising results, reliable success remains elusive. Besides experiments, computational approaches provide a valuable tool to better understand the dynamics of virus spread through a growing population or tumor cells. Combining in vitro experimental approaches with computational models, we study the principles of virus spread through a spatially structured population of cells, which is of fundamental importance to understanding virus treatment of solid tumors. We describe different growth patterns that can occur, interpret them, and explore how they relate to the ability of the virus to induce tumor regression. We further define how these spatial dynamics relate to settings where cells and viruses mix more readily, such as in many cell culture experiments that are used to evaluate candidate viruses.

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Wodarz, D., Hofacre, A., Lau, J. W., Sun, Z., Fan, H., & Komarova, N. L. (2012). Complex spatial dynamics of oncolytic viruses in vitro: Mathematical and experimental approaches. PLoS Computational Biology, 8(6). https://doi.org/10.1371/journal.pcbi.1002547

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