Confocal laser endomicroscopy in neurosurgery: A new technique with much potential

8Citations
Citations of this article
16Readers
Mendeley users who have this article in their library.

Abstract

Technical innovations in brain tumour diagnostic and therapy have led to significant improvements of patient outcome and recurrence free interval. The use of technical devices such as surgical microscopes as well as neuronavigational systems have helped localising tumours as much as fluorescent agents, such as 5-aminolaevulinic acid, have helped visualizing pathologically altered tissue. Nonetheless, intraoperative instantaneous frozen sections and histological diagnosis remain the only method of gaining certainty of the nature of the resected tissue. This technique is time consuming and does not provide close-to-real-time information. In gastroenterology, confocal endoscopy closed the gap between tissue resection and histological examination, providing an almost real-time histological diagnosis. The potential of this technique using a confocal laser endoscope EndoMAG1 by Karl Storz Company was evaluated by our group on pig brains, tumour tissue cell cultures, and fresh human tumour specimen. Here, the authors report for the first time on the results of applying this new technique and provide first confocal endoscopic images of various brain and tumour structures. In all, the technique harbours a very promising potential to provide almost real-time intraoperative diagnosis, but further studies are needed to provide evidence for the technique's potential. © 2013 David Breuskin et al.

Cite

CITATION STYLE

APA

Breuskin, D., Divincenzo, J., Kim, Y. J., Urbschat, S., & Oertel, J. (2013). Confocal laser endomicroscopy in neurosurgery: A new technique with much potential. Minimally Invasive Surgery, 2013. https://doi.org/10.1155/2013/851819

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free