Adenosine to inosine (A-to-I) RNA-editing is an essential post-transcriptional mechanism that occurs in numerous sites in the human transcriptome, mainly within Alu repeats. It has been shown to have consistent levels of editing across individuals in a few targets in the human brain and altered in several human pathologies. However, the variability across human individuals of editing levels in other tissues has not been studied so far.
Greenberger, S., Levanon, E. Y., Paz-Yaacov, N., Barzilai, A., Safran, M., Osenberg, S., … Eisenberg, E. (2010). Consistent levels of A-to-I RNA editing across individuals in coding sequences and non-conserved Alu repeats. BMC Genomics, 11(1). https://doi.org/10.1186/1471-2164-11-608