Constrained cell penetrating peptides

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In this review we provide an overview of recent developments in the field of cell penetrating peptides (CPPs) on research that aims to achieve better control over their transduction properties – one of the big challenges – by means of restraining them. Three different constraining strategies are presented: triggerable activation, backbone rigidification and macrocyclization. Each of these methods have their opportunities in gaining control over CPP activity and selectivity.




Bode, S. A., & Löwik, D. W. P. M. (2017, December 1). Constrained cell penetrating peptides. Drug Discovery Today: Technologies. Elsevier Ltd.

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