Historically, the 5-year survival rates for patients with stage 4 (metastatic) colorectal cancer were extremely poor (5%); however, with advances in systemic chemotherapy combined with an ability to push the boundaries of surgical resection, survival rates in the range of 25-40% can be achieved. This multimodal approach of combining neo-adjuvant strategies with surgical resection has raised a number of questions regarding the optimal management and timing of surgery. For the purpose of this review, we will focus on the treatment of stage 4 colorectal cancer with synchronous liver metastases.
Collins, D., & Chua, H. (2017). Contemporary surgical management of synchronous colorectal liver metastases. F1000Research. Faculty of 1000 Ltd. https://doi.org/10.12688/f1000research.10324.1