Control of cell proliferation in the Drosophila eye by notch signaling

103Citations
Citations of this article
89Readers
Mendeley users who have this article in their library.

Abstract

Cell proliferation in animals must be precisely controlled, but the signaling mechanisms that regulate the cell cycle are not well characterized. A regulated terminal mitosis, called the second mitotic wave (SMW), occurs during Drosophila eye development, providing a model for the genetic analysis of proliferation control. We report a cell cycle checkpoint at the G1-S transition that initiates the SMW, and we demonstrate that Notch signaling is required for cells to overcome this checkpoint. Notch triggers the onset of proliferation by multiple pathways, including the activation of dE2F1, a member of the E2F transcription factor family. Delta to Notch signaling derepresses the inhibition of dE2F1 by RBF, and Delta expression depends on the secreted proteins Hedgehog and Dpp. Notch is also required for the expression of Cyclin A in the SMW. Copyright © 2005 by Elsevier Inc.

Cite

CITATION STYLE

APA

Baonza, A., & Freeman, M. (2005). Control of cell proliferation in the Drosophila eye by notch signaling. Developmental Cell, 8(4), 529–539. https://doi.org/10.1016/j.devcel.2005.01.019

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free