Neocortical circuits can undergo dynamic rearrangements, not only in response to injury, but also when new skills are acquired. But although training can lead to functional rewiring of the cortex, we are far from being able to reprogram an animal by manipulating its cortical circuitry directly.
Schnupp, J. W. H., & Kacelnik, O. (2002, February 19). Cortical plasticity: Learning from cortical reorganisation. Current Biology. Cell Press. https://doi.org/10.1016/S0960-9822(02)00710-8