Cost-effectiveness of treating upper limb spasticity due to stroke with botulinum toxin type a: Results from the botulinum toxin for the upper limb after stroke (BoTULS) trial

  • Trial B
  • Shackley P
  • Shaw L
  • et al.
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Abstract

Stroke imposes significant burdens on health services and society, and as such there is a growing need to assess the cost-effectiveness of stroke treatment to ensure maximum benefit is derived from limited resources. This study compared the \r<br />cost-effectiveness of treating post-stroke upper limb spasticity with botulinum toxin type A plus an upper limb therapy programme against the therapy programme alone. Data on resource use and health outcomes were prospectively collected for 333 patients with \r<br />post-stroke upper limb spasticity taking part in a randomized trial and combined to estimate the incremental cost per quality adjusted life year (QALY) gained of botulinum toxin type A plus therapy relative to therapy alone. The base case incremental \r<br />cost-effectiveness ratio (ICER) of botulinum toxin type A plus therapy was £93,500 per QALY gained. The probability of botulinum toxin type A plus therapy being cost-effective at the England and Wales cost-effectiveness threshold value of £20,000 per QALY was 0.36. The point estimates of the ICER remained above £20,000 per QALY for a range of sensitivity analyses, and the probability of botulinum toxin type A plus therapy being \r<br />cost-effective at the threshold value did not exceed 0.39, regardless of the \r<br />assumptions made.

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Trial, B., Shackley, P., Shaw, L., Price, C., Wijck, F. V., Barnes, M., … Rodgers, H. (2012). Cost-effectiveness of treating upper limb spasticity due to stroke with botulinum toxin type a: Results from the botulinum toxin for the upper limb after stroke (BoTULS) trial. Toxins, 4, 1415–1426. https://doi.org/10.3390/toxins4121415

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