A 2-year-old girl had a craniopharyngioma removed in 1964. She received human growth hormone (HGH) twice a week from July, 1972, until July, 1976. In March, 1984, a subacute dementing illness developed with neurological signs that included pronounced cerebellar ataxia. A clinical diagnosis of Creutzfeldt-Jakob disease (CJD) was made. The patient died in February, 1985. Necropsy revealed a spongiform encephalopathy compatible with the transmissible form of CJD. HGH administration may be implicated in the transmission of the disease in this case. © 1985.
Powell-Jackson, J., Kennedy, P., Whitcombe, E. M., Weller, R. O., Preece, M. A., & Newsom-Davis, J. (1985). CREUTZFELDT-JAKOB DISEASE AFTER ADMINISTRATION OF HUMAN GROWTH HORMONE. The Lancet, 326(8449), 244–246. https://doi.org/10.1016/S0140-6736(85)90292-2