Cross-allergenicity of peanut and lupine: The risk of lupine allergy in patients allergic to peanuts

163Citations
Citations of this article
46Readers
Mendeley users who have this article in their library.

Abstract

Background: Peanut allergy is common, but cross-allergy between legumes is rare. Proteins from Lupinus albus are increasingly eaten in the form of seeds or additives to wheat flour. The risk of cross-allergenicity is still insufficiently known. Objective: We sought to study the risk of cross-allergy to lupine in patients allergic to peanut and to study lupine allergenicity. Methods: Twenty-four patients allergic to peanuts were studied by means of skin prick tests with native lupine flour from Lupinus albus. Double-blind oral challenge tests were performed with lupine flour and peanut in 8 of these patients. Specific IgEs were assayed for peanut, lupine flour, and pollen in 6 sera. RAST inhibition tests for lupine pollen by peanut were performed on 4 of these sera. Peanut and lupine flour immunoblots were carried out for 6 sera, and crossed immunoblot inhibitions for peanut by lupine flour and lupine flour by peanut were carried out for 2 sera. Results: The skin prick test responses with lupine flour were positive in 11 (44%) subjects. The challenge test responses were positive in 7 of 8 subjects at the same doses as with peanut. The major lupine flour allergen (molecular mass, 43 kd) is present in peanuts. The RAST inhibition and immunoblot tests indicated cross-reactivity of peanut with the lupine flour and pollen. Conclusions: The risk of crossed peanut-lupine allergy is high, contrary to the risk with other legumes. The inclusion of 10% lupine flour in wheat flour without mandatory labeling makes lupine a hidden allergen, presenting a major risk of cross-reaction in subjects already allergic to peanut products. A high sensitizing potential can also be postulated for this legume.

Cite

CITATION STYLE

APA

Moneret-Vautrin, D. A., Guérin, L., Kanny, G., Flabbee, J., Frémont, S., & Morisset, M. (1999). Cross-allergenicity of peanut and lupine: The risk of lupine allergy in patients allergic to peanuts. Journal of Allergy and Clinical Immunology, 104(4 I), 883–888. https://doi.org/10.1016/S0091-6749(99)70303-9

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free