Mutations in CIAS1/cryopyrin are linked to several autoinflammatory diseases. In this issue of Immunity, Sutterwala et al. (2006) uncover a critical role for cryopyrin in the caspase-1/IL-1β axis and reveal a broader role for cryopyrin than anticipated. ©2006 Elsevier Inc.
Lich, J. D., Arthur, J. C., & Ting, J. P. Y. (2006, March). Cryopyrin: In from the cold. Immunity. https://doi.org/10.1016/j.immuni.2006.03.004