CtBP family proteins are conserved among vertebrates and invertebrates and function as transcriptional corepressors. They repress transcription in a histone deacetylase-dependent or -independent manner. CtBPs play important roles during development and oncogenesis. In this review, their unusual properties, the mechanisms of transcriptional repression, regulation, and their biological functions are discussed.
Chinnadurai, G. (2002). CtBP, an unconventional transcriptional torepressor in development and oncogenesis. Molecular Cell. Cell Press. https://doi.org/10.1016/S1097-2765(02)00443-4