Culling Less Fit Neurons Protects against Amyloid-β-Induced Brain Damage and Cognitive and Motor Decline

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Abstract

Multicellular organisms eliminate abnormal but viable cells based on their fitness status through cell competition to maintain tissue integrity. Here, Coelho et al. report that fitness-based neuronal selection occurs in the course of neurodegeneration. Death of unfit neurons is beneficial, protecting against disease progression by restoring motor and cognitive functions.

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Coelho, D. S., Schwartz, S., Merino, M. M., Hauert, B., Topfel, B., Tieche, C., … Moreno, E. (2018). Culling Less Fit Neurons Protects against Amyloid-β-Induced Brain Damage and Cognitive and Motor Decline. Cell Reports, 25(13), 3661-3673.e3. https://doi.org/10.1016/j.celrep.2018.11.098

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