Objective: To assess the gonadotrope cell function in patients with polycystic ovary syndrome (PCOS). Methods: This study included 42 patients with polycystic ovary syndrome, aged 26.6 ± 5.9 years, and 13 eumenorrheic controls, aged 30.1 ± 4.6 years. Gonadotropins, sex steroids, sex hormone binding globulin (SHBG), cortisol, thyroid stimulating hormone (TSH), prolactin, free thyroxin, and insulin were measured. Gonadotrope cell function was assessed at baseline and at 30 and 60 min after gonadotropin releasing hormone (GnRH) injection. Results: Luteinizante hormone (LH), prolactin (PRL), total testosterone (T), androstenedione (A), and 17- hidroxyprogesterone (17-OHP4) levels were higher (. P<0.05) and SHBG levels was lower (. P<0.05) in PCOS patients. The LH response to GnRH stimulation was higher in PCOS patients than in controls (P<0.05). Positive correlations between progesterone (P4) and LH at baseline or the area under the curve (AUC) of LH was found only in PCOS patients. No association was found between estradiol (E2), insulin, T, and A concentrations with the LH increment in any group (. P>0.05). Positive correlation between insulin and the AUC of LH was identified in controls. Conclusion: The current study confirms the hypersecretion of LH in PCOS patients after the newest diagnostic systematization. The gonadotrope response to GnRH stimulation in PCOS patients was associated with the baseline levels of LH, P4, insulin.
da Silva Feuser, C. S., Barbosa, J. S., da Silva, E. B., & de Medeiros, S. F. (2014). Current insights into gonadotropic pituitary function in the polycystic ovary syndrome. Asian Pacific Journal of Reproduction, 3(1), 64–70. https://doi.org/10.1016/S2305-0500(14)60004-X