Current scenario of plasmid-mediated colistin resistance in Latin America

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Abstract

Colistin resistance can occur by chromosomal mutations and by acquisition of plasmid-carrying determinants, mainly mcr-1. In the recent years, we have observed the outburst of this resistance gene in our region. Due to the risk of the rapid dissemination of mcr-1, this finding has worried and alerted different actors from the health field and has become one of the most prolific topics. Our review compiles available reports of well-documented mcr-1-positive strains of Enterobacteriaceae, obtained from different samples in Argentina and other countries of Latin America. Furthermore, it addresses the association of mcr-1 with ESBL resistance markers and outlines the platforms involved in their dissemination.

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Quiroga, C., Nastro, M., & Di Conza, J. (2019). Current scenario of plasmid-mediated colistin resistance in Latin America. Revista Argentina de Microbiologia, 51(1), 93–100. https://doi.org/10.1016/j.ram.2018.05.001

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