Current Status of Malaria and Anti-Malarial Drug Resistance in Sri Lanka

  • Rajakaruna R
  • Amerasinghe P
  • Galappaththy G
  • et al.
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Abstract

<p>Even though malaria continues to cause high morbidity and mortality in most of the malaria endemic countries in the world, it is currently not a major health problem in Sri Lanka. Despite the low malaria incidence, the development and spread of anti-malarial drug resistance, combined with a recent increase in the armed conflict hindering provision of effective health services will make it difficult to control malaria in Sri Lanka. Since chloroquine (CQ) resistant <em>Plasmodium falciparum </em>was first reported from Dambulla area in 1984, the number has increased to more than 50% observed <em>in vivo </em>from various endemic areas. In concordance with this, single nucleotide polymorphisms (SNPs) in genes of <em>P. falciparum </em>responsible for CQ resistance are present. A limited number of trials have investigated the efficacy of the second line drug, sulfadoxine/ pyrimethamine (SP) against <em>P. falciparum </em>and a few cases of resistance have been reported. Moreover, SNPs in <em>P. falciparum </em>genes responsible for SP resistance are present and may constitute a sign of evolving SP resistance development. For <em>P. vivax</em>, drug resistance is not yet recorded as a problem in Sri Lanka, however the prevalence of SP resistant SNPs in <em>P. vivax </em>populations seems high and may pose a risk despite that SP is not used directly against <em>P. vivax </em>infections. Continuous monitoring of drug efficacy <em>in vivo</em>, as well by measuring the prevalence of SNPs related to drug resistance are major issues to be addressed.</p> <p>doi: 10.4038/cjsbs.v37i1.493</p> <p><em>Cey. J. Sci. (Bio. Sci.)</em> 37 (1): 15-22, 2008</p>

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APA

Rajakaruna, R. S., Amerasinghe, P. H., Galappaththy, G. N., Konradsen, F., & Briet, O. J. (2009). Current Status of Malaria and Anti-Malarial Drug Resistance in Sri Lanka. Ceylon Journal of Science (Biological Sciences), 37(1), 15. https://doi.org/10.4038/cjsbs.v37i1.493

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