Current Status of Malaria and Anti-Malarial Drug Resistance in Sri Lanka

  • Rajakaruna R
  • Amerasinghe P
  • Galappaththy G
  • et al.
Citations of this article
Mendeley users who have this article in their library.


<p>Even though malaria continues to cause high morbidity and mortality in most of the malaria endemic countries in the world, it is currently not a major health problem in Sri Lanka. Despite the low malaria incidence, the development and spread of anti-malarial drug resistance, combined with a recent increase in the armed conflict hindering provision of effective health services will make it difficult to control malaria in Sri Lanka. Since chloroquine (CQ) resistant <em>Plasmodium falciparum </em>was first reported from Dambulla area in 1984, the number has increased to more than 50% observed <em>in vivo </em>from various endemic areas. In concordance with this, single nucleotide polymorphisms (SNPs) in genes of <em>P. falciparum </em>responsible for CQ resistance are present. A limited number of trials have investigated the efficacy of the second line drug, sulfadoxine/ pyrimethamine (SP) against <em>P. falciparum </em>and a few cases of resistance have been reported. Moreover, SNPs in <em>P. falciparum </em>genes responsible for SP resistance are present and may constitute a sign of evolving SP resistance development. For <em>P. vivax</em>, drug resistance is not yet recorded as a problem in Sri Lanka, however the prevalence of SP resistant SNPs in <em>P. vivax </em>populations seems high and may pose a risk despite that SP is not used directly against <em>P. vivax </em>infections. Continuous monitoring of drug efficacy <em>in vivo</em>, as well by measuring the prevalence of SNPs related to drug resistance are major issues to be addressed.</p> <p>doi: 10.4038/cjsbs.v37i1.493</p> <p><em>Cey. J. Sci. (Bio. Sci.)</em> 37 (1): 15-22, 2008</p>




Rajakaruna, R. S., Amerasinghe, P. H., Galappaththy, G. N., Konradsen, F., & Briet, O. J. (2009). Current Status of Malaria and Anti-Malarial Drug Resistance in Sri Lanka. Ceylon Journal of Science (Biological Sciences), 37(1), 15.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free