In Drosophila, the neuropeptide PDF is required for circadian rhythmicity, but it is unclear where PDF acts. In this issue of Neuron, Shafer et al. use a novel bioimaging methodology to demonstrate that PDF elevates cAMP in nearly all clock neurons. Thus, PDF apparently exerts more widespread effects on the circadian clock network than suggested by previous studies of PDF receptor expression. © 2008 Elsevier Inc. All rights reserved.
Tomchik, S. M., & Davis, R. L. (2008, April 24). Cyclic AMP Imaging Sheds Light on PDF Signaling in Circadian Clock Neurons. Neuron. https://doi.org/10.1016/j.neuron.2008.04.008