Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants

4Citations
Citations of this article
17Readers
Mendeley users who have this article in their library.

Abstract

Macrocyclic peptides have promising therapeutic potential but the scaling up of their chemical synthesis is challenging. The cyanobactin macrocyclase PatGmac is an efficient tool for production but is limited to substrates containing 6-11 amino acids and at least one thiazoline or proline. Here we report a new cyanobactin macrocyclase that can cyclize longer peptide substrates and those not containing proline/thiazoline and thus allows exploring a wider chemical diversity.

Cite

CITATION STYLE

APA

Alexandru-Crivac, C. N., Umeobika, C., Leikoski, N., Jokela, J., Rickaby, K. A., Grilo, A. M., … Houssen, W. E. (2017). Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants. Chemical Communications, 53(77), 10656–10659. https://doi.org/10.1039/c7cc05913b

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free