Cytochrome c release from brain mitochondria is independent of the mitochondrial permeability transition

126Citations
Citations of this article
14Readers
Mendeley users who have this article in their library.

Abstract

Ca2+ uptake by brain mitochondria induces the release of up to 40% of total cytochrome c in a cyclosporin A-insensitive manner. In the presence of ATP and Mg2+, this process is not accompanied by mitochondrial swelling. There is a moderate decrease in membrane potential under these conditions, but it is completely reversible upon removal of accumulated Ca2+ by addition of EGTA+A23187 but not by EGTA alone. These observations provide evidence that cytochrome c release from brain mitochondria does not require the membrane permeability transition. However, brain mitochondria can undergo the permeability transition in the absence of ATP and Mg2+, which results in cyclosporin A-sensitive large amplitude swelling, loss of Ca2+ uptake capacity and release of matrix solutes. Copyright (C) 1998 Federation of European Biochemical Societies.

Cite

CITATION STYLE

APA

Andreyev, A. Y., Fahy, B., & Fiskum, G. (1998). Cytochrome c release from brain mitochondria is independent of the mitochondrial permeability transition. FEBS Letters, 439(3), 373–376. https://doi.org/10.1016/S0014-5793(98)01394-5

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free