Cytotoxicity of, and DNA damage by, active oxygen species produced by xanthine oxidase

22Citations
Citations of this article
7Readers
Mendeley users who have this article in their library.

Abstract

Toxicity to Raji cells of the xanthine oxidase/hypoxanthine system is related to the formation of single-strand DNA breaks. DNA damage was proportional to the concentration of xanthine oxidase and to the time of exposure. It was prevented by the absence of hypoxanthine, or by the presence of allopurinol, or both superoxide dismutase and catalase. The release of 51Cr from damaged cells was detectable 12h after the inhibition of cloning efficiency and the production of DNA breakage. These data suggest that DNA damage induced by the oxygen products precedes the severe lesion to the cellular membrane. © 1991.

Cite

CITATION STYLE

APA

Chiricolo, M., Tazzari, P. L., Abbondanza, A., Dinota, A., & Battelli, M. G. (1991). Cytotoxicity of, and DNA damage by, active oxygen species produced by xanthine oxidase. FEBS Letters, 291(2), 173–176. https://doi.org/10.1016/0014-5793(91)81276-E

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free