Chitosan beads carrying various amino acids (a total of 12 kinds) were synthesized through quite simple procedures for selective removal of low density lipoprotein (LDL). Macroporous chitosan beads were prepared by the phase-inversion method, to which the amino acids were then coupled respectively, via either ethyleneglycol diglycidylether (EGDE) or epichlorohydrin (ECH). Among the amino acids used, in vitro tests proved L-Trp to be the best ligand for binding LDL. The adsorbent, which was prepared by coupling L-Trp to the chitosan beads via EGDE, demonstrated satisfactory adsorption performance for selective removal of LDL in human plasma.
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Fu, G., Yu, H., Yuan, Z., Liu, B., Shen, B., & He, B. (2004). Chitosan adsorbents carrying amino acids for selective removal of low density lipoprotein. Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, 32(2), 303–313. https://doi.org/10.1081/BIO-120037835