Different tumor microenvironments lead to different metabolic phenotypes

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Cancer cells adapt to changes in nutrient and oxygen availability by adopting alternative metabolic pathways.Fatty acid oxidation in cancer cells is a survival mechanism of action to glucose deprivation.Lipid scavenging is utilized to enable cancer cells to survive periods of tumor regression.Distinct, and often complementary, metabolic processes operate concurrently within a single tumor.




Antonio, M. J., & Le, A. (2018). Different tumor microenvironments lead to different metabolic phenotypes. In Advances in Experimental Medicine and Biology (Vol. 1063, pp. 119–129). Springer New York LLC. https://doi.org/10.1007/978-3-319-77736-8_9

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