Nineteen paracentric chromosomal inversions in mice

Abstract

Using mutagens on sperm and spermatids the authors produced 19 chromosomal inversions in mice. The levels of radiation and chemical mutagen used induced inversions in about 1% of the animals screened. Nine inversions were transmitted through successive generations, and the particular frequency of first meiotic anaphase bridges manifested by each inversion remained constant. The cytological properties of first meiotic anaphases varied considerably among the inversions. Chromosomal locations of 5 inversions are known. Four of the 5 are fully viable in homozygous conditions.