Phospholipid transfer protein plays a major role in the initiation of apolipoprotein B-containing lipoprotein assembly in mouse primary hepatocytes

Abstract

Background: Hepatic overproduction of apoB-containing lipoproteins is a risk factor for atherosclerosis. Results: Secretion of apoB:1000-containing lipoproteins is impaired in phospholipid transfer protein (PLTP)-deficient hepatocytes. Conclusion: The initial step in the assembly of primordial apoB-containing lipoproteins is facilitated by PLTP. Significance: Inhibition of PLTP may impede apoB-containing lipoprotein secretion without excessive hepatic lipid accumulation.